Professor Tong Zhang from the Department of Civil Engineering and his team, along with collaborators from various universities and disciplines, worked on the research for the topic “Assessing antimicrobial resistance connectivity across One Health sectors”. The research findings were published in Nature Water on September 29, 2025.
Details of the publication:
Assessing antimicrobial resistance connectivity across One Health sectors
Liguan Li, Bing Li, Xiaole Yin, Yu Xia, Yu Yang, Xiaoqing Xu, Tommy Tsan-Yuk Lam, Kenneth M. Y. Leung, Fujie Xu, Xuxiang Zhang, Jianhua Guo, Heike Schmitt, Gerard D. Wright, Janet Midega, Carlos Bezuidenhout, Renata C. Picão, Shaikh Z. Ahammad, Kornelia Smalla, Steven P. Djordjevic, Amy Pruden, Peter Vikesland, Dominic Frigon, Fiona Walsh, Thomas U. Berendonk, Gianluca Corno, Despo Fatta-Kassinos, Chang-Jun Cha, Nicholas Ashbolt, Guangguo Ying, Yi Luo, Yang Wang, Jianzhong Shen, Yu Zhang, Min Yang, Xiangdong Li, Baolan Hu, Lizhong Zhu, Yongning Wu, Song Tang, Biao Kan, Yong-Guan Zhu, Barth F. Smets, David Graham, Ryo Honda, Eddie Cytryn, Erica Donner, Per Halkjær Nielsen, Mark van Loosdrecht, Michael R. Gillings, William Gaze, Célia M. Manaia, Pedro J. J. Alvarez, Martin J. Blaser, Edward Topp & Tong Zhang
Article in Nature Water
https://www.nature.com/articles/s44221-025-00514-8
Abstract
The first therapeutic use of antimicrobial agents initiated their endless arms race with antimicrobial resistance (AMR). Although the genes encoding antimicrobial resistance are ancient and ubiquitous in various environmental compartments, including aquatic environments, over eight decades of exposure to selective pressure has changed the way antimicrobial resistance genes (ARGs) emerge and transmit among the three One Health sectors (that is, the intersected sectors of humans, animals and the environment). The dissemination of ARGs has been facilitated by the widespread use of antimicrobials, along with direct and secondary pollution pathways. Current global consensus dictates that AMR should be addressed under a One Health framework. AMR National Action Plans have frequently been formulated. However, the capacity for implementation is not ready in most countries, especially in low- and middle-income regions. This is in part due to the substantial challenges in documenting and controlling cross-sector AMR connectivity. Here we describe the past and current status of AMR, emphasizing the contribution of connectivity to global AMR burden. We discuss connectivity at ecological, microbial and genetic levels; propose an approach based on genomics and metagenomics to assess connectivity; and finally advocate for cross-sector studies to better understand AMR connectivity and mitigate dissemination. We believe that such harmonized connectivity studies will facilitate coordinated actions and investments across sectors and regions to scale up AMR management globally.