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"Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors", a paper in Science Advances

Jul 23, 2024

Professor Shiming Zhang of the Department of Electrical and Electronic Engineering and his team worked on the research for the topic “Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors”. The research findings were recently published in Science Advances on April 19, 2024.

Details of the publication:

Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors

Jing Bai, Dingyao Liu, Xinyu Tian, Yan Wang, Binbin Cui, Yilin Yang, Shilei Dai, Wensheng Lin, Jixiang Zhu, Jinqiang Wang, Aimin Xu, Zhen Gu, And Shiming Zhang, article in Science Advances

https://www.science.org/doi/10.1126/sciadv.adl1856

Abstract

Continuous glucose monitoring systems (CGMs) are critical toward closed-loop diabetes management. The field’s progress urges next-generation CGMs with enhanced antinoise ability, reliability, and wearability. Here, we propose a coin-sized, fully integrated, and wearable CGM, achieved by holistically synergizing state-of-the-art interdisciplinary technologies of biosensors, minimally invasive tools, and hydrogels. The proposed CGM consists of three major parts: (i) an emerging biochemical signal amplifier, the organic electrochemical transistor (OECT), improving the signal-to-noise ratio (SNR) beyond traditional electrochemical sensors; (ii) a microneedle array to facilitate subcutaneous glucose sampling with minimized pain; and (iii) a soft hydrogel to stabilize the skin-device interface. Compared to conventional CGMs, the OECT-CGM offers a high antinoise ability, tunable sensitivity and resolution, and comfort wearability, enabling personalized glucose sensing for future precision diabetes health care. Last, we discuss how OECT technology can help push the limit of detection of current wearable electrochemical biosensors, especially when operating in complicated conditions.