People

Barbara P. Chan

RESEARCH INTERESTS:

  • Tissue engineering and regeneration
  • Biosurgery, laser medicine
  • Mechanoregulation
  • Stem cells and biomaterial interactions

BIOGRAPHY:

Dr. Chan completed her undergraduate studies in Biochemistry at the Chinese University of Hong Kong in 1994. She obtained her Ph.D. in Surgical Science Division of the Faculty of Medicine from CUHK in 1998 and finished her first post-doctoral fellowship in Orthopaedics and Traumatology in the same institution in 1999. Dr. Chan then joined the Innovation and Technology Commission participating in the operation of the Small Entrepreneur Research Assistant Program under the Innovation and Technology Fund. After a one-year service in the government, she received her second postdoctoral fellowship in the Wellman Laboratories for Photomedicine, Massachusetts General Hospital in Harvard Medical School. Dr. Chan moved back to Hong Kong in 2002 and worked in the CK Life Sciences Int’l Inc. as a project manager. She joined the Department of Mechanical Engineering in the University of Hong Kong in 2003. Her main research interests are tissue engineering and regeneration, biosurgery, laser medicine, stem cells and biomaterial interactions, and mechanoregulation..

SELECTED PUBLICATIONS:

  • Au-yeung KL, Sze KY, Sham MH, B.P. Chan, Development of a micromanipulator-based loading device for mechanoregulation study of human mesenchymal stem cells in 3D collagen constructs. 2009, Tissue Engineering, Part C (In press)
  • Yeung CW, Chan D, Cheah K, B.P. Chan, Three dimensional culture and embryoid body-free chondrogenic differentiation of mouse embryonic stem cells in collagen microspheres. 2009, Tissue Engineering, Part A. (In press)
  • Cheng HW, Tsui K, Cheung KMC, Chan D, B.P. Chan, Decellularization of chondrocyte-encapsulated collagen microspheres – A 3D model to study the effects of acellular matrix on stem cell fate. 2009, Tissue Engineering Part C. (In press)
  • Lee M, Lo AC, Cheung PT, Wong D, B.P. Chan, GDNF-secreting HEK293 cells in collagen-alginate composite gel and collagen microspheres embedded in alginate gel – New carrier designs for drug delivery applications. 2009, Biomaterials 30: 1214-1221.
  • B.P. Chan, Leong KW. Scaffolding in tissue engineering – General approaches and tissue-specific considerations, 2008, Eur. J Spine 2008; 17 Suppl 4:467-79.
  • B.P. Chan, So KF. Effects of photochemical crosslinking on microstructure and protein release of collagen. 2008, Acta Biomaterialia 4: 1627-1636.
  • Chan OCM, So KF, B.P. Chan, Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. 2008, Journal of Controlled Release 129(2):135-43.
  • B.P. Chan, Li CH, Au-yeung,KL, Sze KY, Ngan AHW. A microplate compression method for elastic modulus measurement of soft and viscoelastic collagen microspheres. 2008, Ann. Biomed Eng 36(7): 1254-1267.
  • Hui TY, Cheung KMC, Cheung WL, Chan D, B.P. Chan, In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration. Biomaterials 29, 2008, 3201-3212.
  • Wong HL, Wang MX, Cheung PT, Yao KM, B.P. Chan, A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity. 2007, Biomaterials 28: 5369-5380.
  • B.P. Chan, Hui TY, Yeung CW, Li J, Mo I, Chan GCF. Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine. Biomaterials 28, 2007, 4652–4666.
  • B.P. Chan, Hui TY, Chan OC, So KF, Lu W, Cheung KM, Salomatina E, Yaroslavsky A. Photochemical Cross-Linking for Collagen-Based Scaffolds: A Study on Optical Properties, Mechanical Properties, Stability, and Hematocompatibility. Tissue Eng. 2007; 13(1):73-85